Apixaban Drug

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Apixaban: MedlinePlus Drug Information

(Just Now) Apixaban comes as a tablet to take by mouth. It is usually taken with or without food twice a day. When apixaban is taken to prevent DVT and PE after hip or knee replacement surgery, the first dose should be taken at least 12 to 24 hours after surgery. Apixaban is usually taken for 35 days after a hip replacement surgery and for 12 days after

Medlineplus.gov

Category:  Health Detail Drugs


Apixaban Uses, Side Effects & Warnings - Drugs.com

(9 days ago) Warnings. Apixaban increases your risk of severe or fatal bleeding, especially if you take certain medicines at the same time (including some over-the-counter medicines).Tell your doctor about all medicines you have recently used. Call your doctor at once if you have signs of bleeding such as: easy bruising, unusual bleeding, unexpected pain or swelling, feeling very weak or dizzy, …

Drugs.com

Category:  Doctor Detail Drugs


Apixaban - Wikipedia

(8 days ago) Apixaban, sold under the brand name Eliquis, is an anticoagulant medication used to treat and prevent blood clots and to prevent stroke in people with nonvalvular atrial fibrillation through directly inhibiting factor Xa. Specifically it is used to prevent blood clots following hip or knee replacement and in those with a history of prior clots. It is used as an alternative to warfarin …

En.wikipedia.org

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Apixaban: Uses, Interactions, Mechanism of Action

(7 days ago) Generic Name Apixaban DrugBank Accession Number DB06605 Background. Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases Label,2.It is marketed under the name Eliquis Label,3.Apixaban

Go.drugbank.com

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Eliquis: Uses, Dosage & Side Effects Information - Drugs.com

(4 days ago) Eliquis ( apixaban) blocks the activity of certain clotting substances in the blood. Eliquis is used to lower the risk of stroke or a blood clot in people with a heart rhythm disorder called atrial fibrillation. Eliquis reduces the risk of forming a blood clot in the legs and lungs of people who have just had hip or knee replacement surgery.

Drugs.com

Category:  Lung,  Heart Detail Drugs


Apixaban (Eliquis) Davis’s Drug Guide

(1 days ago) Find information on Apixaban (Eliquis) in Davis’s Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.

Drugguide.com

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What is apixaban? DRAFT - Health Online

(Just Now) This handout explains the medicine apixaban, a drug that helps prev ent and treat blood clots. What is apixaban? Apixaban (brand name Eliquis) is an anticoagulant medicine. “Anti” means against, and “coagulant” refers to blood clotting. An anticoagulant helps keep clots from forming in your blood. Apixaban is sometimes called a

Healthonline.washington.edu

Category:  Health Detail Drugs


Apixaban Drug Interaction Potential Anticoagulation Services

(6 days ago) Apixaban Drug Interaction Potential Pharmacodynamic Interactions The concurrent use of apixaban with other anticoagulants , antiplatelet agents , and nonsteroidal anti-inflammatory agents is expected to increase the risk of bleeding in comparison to use of apixaban alone.

Depts.washington.edu

Category:  Health Detail Drugs


Treatment with Apixaban - University of Washington

(4 days ago) This handout explains the medicine apixaban, a drug that helps prevent blood clots. What is apixaban? Apixaban (brand name Eliquis) is an anticoagulant medicine. “Anti” means against, and “coagulant” refers to blood clotting. An anticoagulant helps keep clots from forming in …

Depts.washington.edu

Category:  Health Detail Drugs


Apixaban Prices and Apixaban Coupons - GoodRx

(1 days ago) apixaban has been approved by the FDA, but isn’t available in pharmacies yet.. Drugs may be approved days, weeks, or months before they’re launched, so we encourage you to check back. As soon as apixaban is released, we’ll have prices from a variety of pharmacies and other places where you can buy it.. We also offer other information about apixaban, including potential side …

Goodrx.com

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Measuring Apixaban Levels UW Medicine Anticoagulation

(9 days ago) APIXABAN ASSAY (APIXN1) Uses chromogenic anti-Xa activity to extrapolate apixaban concentrations in ng/mL. Lower limit of measurable range is < 20 ng/mL. Measuring the presence of apixaban may be helpful to: assure absence of drug prior to invasive procedures. assure absence of drug prior to use of thrombolytic therapy.

Sites.uw.edu

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FDA approves first generics of Eliquis FDA

(7 days ago) Apixaban will be dispensed with a Medication Guide for patients that provides instructions on its use and drug safety information. Health care professionals should counsel patients on signs and

Fda.gov

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Drug interactions with apixaban: A systematic review of

(1 days ago) Apixaban, a direct oral anticoagulant, has emerged over the past few years because it is considered to have a low risk of drug-drug interactions compared to vitamin K antagonists. To better characterize these interactions, we systematically reviewed studies evaluating the drug-drug interactions invo …

Pubmed.ncbi.nlm.nih.gov

Category:  Vitamin Detail Drugs


Apixaban drug information HelloPharmacist

(2 days ago) Apixaban is also used to treat DVT and PE and may be continued to prevent DVT and PE from happening again after the initial treatment is completed. Apixaban is in a class of medications called factor Xa inhibitors. It works by blocking the action of a certain natural substance that helps blood clots to form.

Hellopharmacist.com

Category:  Medications Detail Drugs


apixaban oral: Uses, Side Effects, Interactions, Pictures

(3 days ago) Apixaban is used to prevent serious blood clots from forming due to a certain irregular heartbeat (atrial fibrillation) or after hip/knee replacement surgery.With atrial fibrillation, part of the

Webmd.com

Category:  Heart Detail Drugs


Apixaban (Eliquis): Side Effects, Dosages, Treatment

(8 days ago) Apixaban is a blood thinner that reduces blood clotting and the risk of stroke. Learn about side effects, drug interactions, dosages, warnings, and more.

Rxlist.com

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A rare side effect seen due to the use of apixaban

(3 days ago) Introduction. Psoriasiform drug eruptions are very rare and generally characterized as erythematous, thick, dry, squamous, and demarcated plaques, resembling those of idiopathic psoriasis ().Drugs may result in the exacerbation of pre-existing psoriasis or initiation of de novo psoriatic lesions ().Apixaban, a reversible direct inhibitor factor Xa, is a novel anticoagulant, …

Ncbi.nlm.nih.gov

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Apixaban - FDA prescribing information, side effects and uses

(9 days ago) Apixaban is metabolized mainly via CYP3A4 with minor contributions from CYP1A2, 2C8, 2C9, 2C19, and 2J2. O-demethylation and hydroxylation at the 3-oxopiperidinyl moiety are the major sites of biotransformation. Unchanged Apixaban is the major drug-related component in human plasma; there are no active circulating metabolites. Elimination

Drugs.com

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Apixaban C25H25N5O4 - PubChem

(Just Now) Apixaban is metabolized mainly via CYP3A4 with minor contributions from CYP1A2, 2C8, 2C9, 2C19, and 2J2. O-demethylation and hydroxylation at the 3-oxopiperidinyl moiety are the major sites of biotransformation. Unchanged apixaban is the major drug-related component in human plasma; there are no active circulating metabolites.

Pubchem.ncbi.nlm.nih.gov

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Apixaban Dosage Guide + Max Dose, Adjustments - Drugs.com

(2 days ago) Detailed Apixaban dosage information for adults. Includes dosages for Prevention of Thromboembolism in Atrial Fibrillation, Deep Vein Thrombosis, Thromboembolic Stroke Prophylaxis and more; plus renal, liver and dialysis adjustments.

Drugs.com

Category:  Health Detail Drugs


Apixaban: Side Effects, Dosage, Uses, and More

(Just Now) Apixaban oral tablet is a prescription drug used to treat and prevent blood clots such as deep vein thrombosis (DVT) and pulmonary embolism (PE). …

Healthline.com

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Clinical and Pharmacological Effects of Apixaban Dose

(1 days ago) Apixaban drug concentrations were lower in patients receiving 2.5 mg twice daily compared with 5 mg twice daily. However, the effects of apixaban dose adjustment to 2.5 mg versus warfarin were consistent for coagulation biomarkers and clinical outcomes, providing reassuring data on efficacy and safe …

Pubmed.ncbi.nlm.nih.gov

Category:  Health Detail Drugs


Apixaban (Oral Route) Side Effects - Mayo Clinic

(Just Now) nosebleeds. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue. redness of the eye. severe stomach pain. shortness of breath. tightness in the chest. unusual tiredness or weakness. vomiting of blood or material that looks like coffee grounds. Other side effects not listed may also occur in some patients.

Mayoclinic.org

Category:  Health Detail Drugs


apixaban Uses, Side Effects, Dosage & Interactions

(1 days ago) Apixaban increases your risk of severe or fatal bleeding, especially if you take certain medicines at the same time (including some over-the-counter medicines).It is very important to tell your doctor about all medicines you have recently used. Call your doctor at once if you have signs of bleeding such as: swelling, pain, feeling very weak or dizzy, bleeding gums, nosebleeds, …

Igeeksblogs.en.dyndns.ws

Category:  Doctor Detail Drugs


Apixaban Dose Adjustments and Drug Interactions - Med Ed 101

(9 days ago) The usual dose of apixaban in atrial fibrillation is 5 mg twice daily. If the patient has two of the above three factors, the apixaban dose should be reduced to 2.5 mg twice daily. Apixaban Drug Interactions. Apixaban is not free from drug interactions.

Meded101.com

Category:  Health Detail Drugs


Apixaban Monograph for Professionals - Drugs.com

(5 days ago) Reduce apixaban dosage by 50% if patient receiving >2.5 mg twice daily; avoid concomitant use if patient already receiving 2.5 mg twice daily. Avoid concomitant use of ketoconazole and apixaban in patients with ≥2 of the following characteristics: age ≥80 years, body weight ≤60 kg, S cr ≥1.5 mg/dL. Aspirin. Increased bleeding risk observed

Drugs.com

Category:  Health Detail Drugs


Apixaban - LiverTox - NCBI Bookshelf

(5 days ago) Apixaban is an oral anticoagulant and direct inhibitor of factor Xa which is used to decrease the risk of venous thromboses, systemic embolization and stroke in patients with atrial fibrillation, and lower the risk of deep vein thrombosis and pulmonary embolus after knee or hip replacement surgery. Apixaban has been linked to a low rate of serum aminotransferase elevations during …

Ncbi.nlm.nih.gov

Category:  Health Detail Drugs


Apixaban: A Clinical Pharmacokinetic and Pharmacodynamic

(3 days ago) After an oral dose of apixaban, unchanged apixaban is the major drug-related component in human plasma with no active circulating metabolites present . When a 20-mg radiolabeled dose was administered orally, 56.0% of the dose was recovered in feces and 24.5% was eliminated in urine and unchanged apixaban was the major component in both feces

Ncbi.nlm.nih.gov

Category:  Health Detail Drugs


Apixaban: Dosage, Mechanism/Onset of Action, Half-Life

(2 days ago) Dosage adjustment of apixaban with concomitant medications: Strong dual CYP3A4 and P-glycoprotein inhibitors (eg, ketoconazole, itraconazole, ritonavir): Recommended apixaban doses >2.5 mg twice daily: Reduce apixaban dose by 50%. Recommended apixaban dose of 2.5 mg twice daily: Avoid concomitant use.

Medicine.com

Category:  Medications Detail Drugs


Reference ID: 3237516 - Food and Drug Administration

(5 days ago) ELIQUIS increases the risk of bleeding and can cause serious, potentially fatal, bleeding [see Dosage and Administration (2.2) and Adverse Reactions (6.1)]. Concomitant use of drugs affecting hemostasis increases the risk of bleeding. These include aspirin and other antiplatelet agents, other anticoagulants, heparin, thrombolytic agents, selective

Accessdata.fda.gov

Category:  Health Detail Drugs


Dosing Guide - ELIQUIS

(4 days ago) Reduce dose by 50%: For patients receiving ELIQUIS® (apixaban) doses of 5 mg or 10 mg twice daily, when ELIQUIS is coadministered with drugs that are combined P-gp and strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, or ritonavir). Clarithromycin Although clarithromycin is a combined P-gp and strong CYP3A4 inhibitor, pharmacokinetic

Eliquis.com

Category:  Health Detail Drugs


Apixaban: Indications, Drug Interactions & Side Effects

(9 days ago) As with any drug, apixaban may have important drug interactions that either decrease its important effectiveness or increase the chances of a major side effect. For …

Study.com

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MEDICATION GUIDE ELIQUIS (ELL eh kwiss) (apixaban) tablets

(Just Now) What is ELIQUIS? ELIQUIS is a prescription medicine used to: reduce the risk of stroke and blood clots in people who have atrial fibrillation.

Fda.gov

Category:  Health Detail Drugs


Apixaban: a new player in the anticoagulant class

(1 days ago) The Apixaban based drug will be marketed under the brand name Eliquis® and is expected to rack up annual sales of over $2.5 billion. Apixaban is expected to provide stiff competition to warfarin, a popular blood thinner used in Europe. Warfarin is known to cause some serious side effects in patients.

Pubmed.ncbi.nlm.nih.gov

Category:  Health Detail Drugs


Chromogenic anti-FXa assay calibrated with low molecular

(3 days ago) Introduction. Clinical application of rivaroxaban and apixaban does not require therapeutic monitoring. Commercial anti-activated factor X (anti-FXa) inhibition methods for all anti-FXa drugs are based on the same principle, so there are attempts to evaluate potential clinical application of heparin-calibrated anti-FXa assay as an alternative method for direct FXa inhibitors.

Ncbi.nlm.nih.gov

Category:  Health Detail Drugs


Apixaban Pharmacology, Medicinal Chemistry and Drug Design

(Just Now) Apixaban (Eliquis) is a novel anticoagulant with indications for deep vein thrombosis (DVT), pulmonary embolism (PE), atrial fibrillation, and prophylactic risk reduction of recurrence. While on a retail rotation at Walgreens, a patient was found with two drug interactions involving apixaban, which were ibuprofen and fluvoxamine.

Cbm.msoe.edu

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Randomized phase 2 trial comparing JNJ-9375, a thrombin

(1 days ago) There were no major bleeds with JNJ-9375 or apixaban, and rates of any bleeding were similar with the highest and lowest JNJ-9375 doses. Conclusions: JNJ-9375 was safe but less effective than apixaban. This may reflect weak thrombin inhibition or inability of JNJ-9375 to attenuate the growth of thrombi that formed before drug administration.

Pubmed.ncbi.nlm.nih.gov

Category:  Health Detail Drugs


Eliquis (apixaban) dose, indications, adverse effects

(4 days ago) The apixaban manufacturer recommends reducing the apixaban dose by 50% when coadministered with drugs that are both strong inhibitors of CYP3A4 and P-gp, such as darunavir. If patients are already receiving 2.5 mg twice daily, avoid …

Pdr.net

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Generic Drug Substitute For Eliquis and Similar Products

(8 days ago) Apixaban (Eliquis) is an expensive drug used to lower the chance of stroke in people with a medical condition called atrial fibrillation. It is also used to …

Listalternatives.com

Category:  Health Detail Drugs


Eliquis (apixaban) dosing, indications, interactions

(9 days ago) For patients receiving apixaban 5 or 10 mg BID, decrease apixaban dose by 50% when coadministered with drugs that are both P-gp and strong CYP3A4 inhibitors. For patients receiving apixaban 5 mg BID, avoid coadministration …

Reference.medscape.com

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Evaluation of a Heparin-Calibrated Antifactor Xa Assay for

(7 days ago) When comparing the proposed antifactor Xa activity ranges for patients therapeutically treated with apixaban or rivaroxaban within this study, there is a marked difference between the antifactor Xa activities expected at peak drug concentrations between the two agents, despite relatively similar expected antifactor Xa activities at trough drug

Journals.sagepub.com

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Drug-Drug Interaction Study of Apixaban with Cyclosporine

(1 days ago) Apixaban is metabolized by cytochrome P450 (CYP) 3A4 in the liver and intestine, undergoes direct intestinal excretion, and is a substrate to permeability glycoprotein (P-gp) and breast cancer resistance protein (BCRP) transporters. We examined …

Pubmed.ncbi.nlm.nih.gov

Category:  Cancer Detail Drugs


Drug interactions with apixaban: A systematic review of

(5 days ago) macodynamic drug-drug interactions. These data suggest that apixaban has signif-icant potential for drug-drug interactions, either with CYP3A/P-gp modulators or with drugs that may impair hemostasis. The most described adverse drug reactions were adverse drug reactions related to hemorrhage or thrombosis, mostly through pharmacodynamic

Bpspubs.onlinelibrary.wiley.com

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Apixaban versus Warfarin in Patients with Atrial

(6 days ago) Apixaban had an acceptable side-effect profile, with no unexpected side effects, and the rate of discontinuation of the study drug was lower in the apixaban group than in the warfarin group.

Nejm.org

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Drug Information Portal - U.S. National Library of

(4 days ago) The NLM Drug Information Portal gives users a gateway to selected drug information from the National Library of Medicine and other key government agencies. …

Druginfo.nlm.nih.gov

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