Rofecoxib Drug

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Rofecoxib: Uses, Interactions, Mechanism of Action

(7 days ago) 1347 rows · Rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is classified as a …

Go.drugbank.com

Category:  Health Detail Drugs


rofecoxib (Vioxx): Drug Facts, Side Effects and Dosing

(9 days ago) Rofecoxib is a nonsteroidal anti-inflammatory drug that is used to treat pain, particularly the pain of osteoarthritis and menstrual cramps. Prostaglandins are chemicals that are important in promoting inflammation and its signs--pain, fever , swelling and tenderness.

Medicinenet.com

Category:  Health Detail Drugs


Rofecoxib Oral: Uses, Side Effects, Interactions, Pictures

(3 days ago) Find patient medical information for rofecoxib oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. precautions, drug interactions or

Webmd.com

Category:  Health Detail Drugs


Vioxx (Rofecoxib): Uses, Dosage, Side Effects

(7 days ago) Rofecoxib is eliminated predominantly by hepatic metabolism with little ( < 1%) unchanged drug recovered in the urine. Following a single radiolabeled dose of 125 mg, approximately 72% of the dose was excreted into the urine as metabolites and 14% in the feces as unchanged drug.

Rxlist.com

Category:  Health Detail Drugs


Drug Regulation: Rofecoxib (Vioxx) voluntarily withdrawn

(2 days ago) Rofecoxib, which is available in more than 80 countries, had worldwide sales of $2.5 billion in 2003. IMS Health Canada reports that rofecoxib was the number 10 top-selling drug in Canada in 2003, with 3.3 million prescriptions written and retail sales totalling $194 million. “The fact that so many are prescribed is unfortunate,” says Wright.

Ncbi.nlm.nih.gov

Category:  Health Detail Drugs


Vioxx: Side Effects, Dosage & Uses - Drugs.com

(2 days ago) Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 6 Dec 2021), Cerner Multum™ (updated 1 …

Drugs.com

Category:  Health Detail Drugs


The rofecoxib scandal The BMJ

(3 days ago) seventh position, Rofecoxib (annual turnover: $2.6bn) the tenth position. of the best selling drugs worlwide (1). Since the VIGOR (Vioxx Gastrointestinal Research) study was published. in 2000 in the New England Journal of Medicine, rofecoxib has been. associated with cardiovascular complications (2).

Bmj.com

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Reporting Mortality Findings in Trials of Rofecoxib for

(2 days ago) of Rofecoxib for Alzheimer Disease or Cognitive Impairment A Case Study Based on Documents From Ro fecoxib Litigation Bruce M. Psaty, MD, PhD continued the study drug until the end of the trial, an approach that permitted intention-to-treat analyses for the mor-tality end point.

Depts.washington.edu

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What have we learnt from Vioxx?

(3 days ago) Rofecoxib (Vioxx) was introduced by Merck in 1999 as an effective, safer alternative to non-steroidal anti-inflammatory drugs for the treatment of pain associated with osteoarthritis. It was subsequently found to increase the risk of cardiovascular disease and withdrawn from the worldwide market.

Ncbi.nlm.nih.gov

Category:  Health Detail Drugs


Vioxx (rofecoxib) Questions and Answers FDA

(1 days ago) Vioxx (rofecoxib) Questions and Answers. [9/30/2004] 1. What action did Merck take today? Merck announced a voluntary worldwide withdrawal …

Fda.gov

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Rofecoxib: clinical pharmacology and clinical experience

(1 days ago) Background: Rofecoxib is a member of a subgroup of nonsteroidal anti-inflammatory drugs (NSAIDs) known as cyclooxygenase-2 (COX-2)-selective inhibitors. It has been studied in adult and elderly patients in a number of painful conditions (primary dysmenorrhea, acute pain after dental and orthopedic surgery, osteoarthritis [OA], and rheumatoid arthritis).

Pubmed.ncbi.nlm.nih.gov

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Rofecoxib (Vioxx) Davis’s Drug Guide

(Just Now) Find information on Rofecoxib (Vioxx) in Davis’s Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.

Drugguide.com

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Failing the Public Health — Rofecoxib, Merck, and the FDA

(9 days ago) Failing the Public Health — Rofecoxib, Merck, and the FDA. List of authors. On May 21, 1999, Merck was granted approval by the Food and Drug Administration (FDA) to …

Nejm.org

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Vioxx Information : Rofecoxib : Johns Hopkins Information

(1 days ago) The makers of VIOXX® removed this drug from the market on 9/30/04. What is Rofecoxib (Vioxx®)? Rofecoxib is commonly known by the brand name Vioxx®. Rofecoxib (Ro-fe-COX-eb) is used to relieve some symptoms caused by arthritis, such as inflammation, swelling, stiffness, and joint pain.

Hopkinsarthritis.org

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Rofecoxib - an overview ScienceDirect Topics

(7 days ago) The drug is administered orally, its bioavailability is 93%, and 87% of the absorbed dose is bound to plasma proteins. 136 The metabolism of rofecoxib in the liver yields metabolites that have no COX-1 or COX-2 activity. Though metabolized by the liver, adjustment in dosage for patients with liver disease is not necessary.

Sciencedirect.com

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Could Vioxx Make a Comeback? Recalled Drug Receives Orphan

(9 days ago) Recalled Drug Receives Orphan Designation. Despite a troubling history, rofecoxib (Vioxx) may be making a comeback. The voluntary withdrawal of rofecoxib (Vioxx) from the market in September 2004 marked the end of a controversial era for a once highly profitable and widely used drug. It also marked the beginning of years of high-profile product

Blog.petrieflom.law.harvard.edu

Category:  Health Detail Drugs


Rofecoxib - an overview ScienceDirect Topics

(9 days ago) The drug is administered orally, its bioavailability is 93%, and 87% of the absorbed dose is bound to plasma proteins.136 The metabolism of rofecoxib in the liver yields metabolites that have no COX-1 or COX-2 activity. Though metabolized by the liver, adjustment in dosage for patients with liver disease is not necessary.

Sciencedirect.com

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VIOXX®( rofecoxib tablets and oral suspension) DESCRIPTION

(Just Now) 3 85 86 Excretion 87 Rofecoxib is eliminated predominantly by hepatic metabolism with little (<1%) unchanged 88 drug recovered in the urine. Following a single radiolabeled dose of 125 mg, 89 approximately 72% of the dose was excreted into the urine as metabolites, and 14% in the 90 feces as unchanged drug. 91 92 The plasma clearance after 12.5 and 25 mg doses was …

Accessdata.fda.gov

Category:  Health Detail Drugs


Rofecoxib Adam La Caze

(8 days ago) Rofecoxib Pre-clinical information Phase I Phase II Phase III Post-market problems References Rofecoxib Pre-clinical information NSAIDs are essential drugs for the management of acute and chronic pain and inflammation. Serious adverse effects limit the usefulness of NSAIDs, especially gastrointestinal adverse effects and effects on renal function.

Alacaze.net

Category:  Health Detail Drugs


Side Effects of Vioxx (Rofecoxib), Warnings, Uses

(7 days ago) Vioxx (rofecoxib) is a nonsteroidal anti-inflammatory drug used to reduce pain, inflammation, and stiffness caused by osteoarthritis, rheumatoid arthritis and certain forms of juvenile rheumatoid arthritis; to manage acute pain in adults; to treat migraines; and to treat menstrual pain.The brand name Vioxx was withdrawn from the U.S. market in 2004 and is no …

Rxlist.com

Category:  Health Detail Drugs


The Lessons of Vioxx — Drug Safety and Sales NEJM

(9 days ago) This pamphlet, prepared by Merck's marketing department, indicated that rofecoxib was associated with 1/8 the mortality from cardiovascular causes of that found with other antiinflammatory drugs.

Nejm.org

Category:  Health Detail Drugs


Rofecoxib Dosage Guide + Max Dose, Adjustments - Drugs.com

(3 days ago) Rofecoxib was voluntarily withdrawn from the market in September, 2004 by the manufacturer due to an increased risk of serious cardiovascular events, including heart attacks and strokes among patients taking the drug chronically. The following dosage information applies to when the drug was available in the USA. 12.5 mg orally once daily.

Drugs.com

Category:  Heart Detail Drugs


Rofecoxib C17H14O4S - PubChem

(1 days ago) Rofecoxib C17H14O4S CID 5090 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety

Pubchem.ncbi.nlm.nih.gov

Category:  Health Detail Drugs


VIOXX® - Food and Drug Administration

(7 days ago) appropriately monitored. Drug interaction studies do not support the potential for clinically important interactions between antacids or cimetidine with rofecoxib. Similar to experience with other nonsteroidal anti-inflammatory drugs (NSAIDs), studies with rofecoxib suggest the potential for interaction with ACE inhibitors.

Accessdata.fda.gov

Category:  Health Detail Drugs


Reporting mortality findings in trials of rofecoxib for

(1 days ago) In another article (reporting results of protocol 078) published in 2005, 39 deaths were reported among patients taking study treatment or within 14 days of the last dose (24 among 725 rofecoxib patients and 15 among 732 placebo patients) and an additional 22 deaths in the off-drug period (17 in rofecoxib patients and 5 in placebo patients).

Pubmed.ncbi.nlm.nih.gov

Category:  Health Detail Drugs


Rofecoxib (Vioxx) - Florida State University

(5 days ago) Rofecoxib (Vioxx) Vioxx is a non-steroidal anti-inflammatory drug ( NSAID) that contains the active ingredient rofecoxib. The drug has been most commonly prescribed to treat osteoarthritis, rheumatoid arthritis, pain, and migraines. The mechanism of action of Vioxx involves the inhibition of the enzyme cyclooxygenase-2 ( COX-2 ), which

Micro.magnet.fsu.edu

Category:  Health Detail Drugs


Rofecoxib Efficacy and Safety Evaluation Trial in

(1 days ago) This is a multicenter, randomized, double-blind study to evaluate the efficacy and safety of TRM-201 (rofecoxib) versus Placebo in the treatment of patients with hemophilic arthropathy (HA) over a 12-week period (Part I) that is followed by a year-long (52 week) open-label extension (Part II) to further evaluate the safety and maintenance of efficacy of TRM-201.

Clinicaltrials.gov

Category:  Health Detail Drugs


rofecoxib oral Interactions with Other Medication

(1 days ago) The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of …

Webmd.com

Category:  Health Detail Drugs


Cost-efficacy of Rofecoxib versus Acetaminophen for

(8 days ago) It is possible that the combination would have been more effective than either drug alone if a lower dose of rofecoxib (25 mg) had been used in the study. Although all patients were discharged home with similar pain scores, fewer patients in the rofecoxib and the rofecoxib–acetaminophen groups required rescue analgesic medication in the

Pubs.asahq.org

Category:  Health Detail Drugs


Rofecoxib - chemeurope.com

(7 days ago) Rofecoxib was approved as safe and effective by the Food and Drug Administration (FDA) on May 20, 1999 and was subsequently marketed under the brand name Vioxx, Ceoxx and Ceeoxx. Rofecoxib gained widespread acceptance among physicians treating patients with arthritis and other conditions causing chronic or acute pain.

Chemeurope.com

Category:  Health Detail Drugs


Side Effects of Vioxx (rofecoxib): Interactions & Warnings

(6 days ago) The concomitant use of rofecoxib and anticoagulants have an increased risk of serious bleeding compared to the use of either drug alone. In single and multiple dose studies in healthy subjects receiving both warfarin and rofecoxib, prothrombin time (measured as INR) was increased by approximately 8% to 11%.

Medicinenet.com

Category:  Health Detail Drugs


Rofecoxib - BioHarmony

(8 days ago) Vioxx (rofecoxib) is a small molecule pharmaceutical. Rofecoxib was first approved as Vioxx on 1999-05-20. It is used to treat dysmenorrhea and osteoarthritis in the USA. The pharmaceutical is active against prostaglandin G/H synthase 2.

Biometadata.com

Category:  Pharmaceutical Detail Drugs


Rofecoxib - FPnotebook.com

(8 days ago) A drug that was being used for pain relief and was being studied for its ability to prevent cancer and to prevent the growth of new blood vessels that tumors need to grow. It is a type of nonsteroidal anti-inflammatory drug and a type of antiangiogenesis agent. Rofecoxib was taken off the market in the U.S. because of safety concerns.

Fpnotebook.com

Category:  Cancer Detail Drugs


Rofecoxib - ScienceDaily

(8 days ago) Rofecoxib is a nonsteroidal anti-inflammatory drug that was used in the treatment of osteoarthritis, acute pain conditions, and dysmenorrhoea. Formerly marketed by Merck & Co. under the trade

Sciencedaily.com

Category:  Health Detail Drugs


Rofecoxib: Indication, Dosage, Side Effect, Precaution

(2 days ago) Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) Disclaimer: This information is independently developed by MIMS based on Rofecoxib from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries.

Mims.com

Category:  Health Detail Drugs


DGIdb - ROFECOXIB Drug Record

(7 days ago) Matheson et al., 2001, Rofecoxib: a review of its use in the management of osteoarthritis, acute pain and rheumatoid arthritis., Drugs Hawkey et al., 2000, Comparison of the effect of rofecoxib (a cyclooxygenase 2 inhibitor), ibuprofen, and placebo on the gastroduodenal mucosa of patients with osteoarthritis: a randomized, double-blind, placebo

Dgidb.org

Category:  Health Detail Drugs


Rofecoxib - Australian Prescriber

(3 days ago) Rofecoxib has a half-life of 17 hours and can be taken once a day. Each dose is well absorbed resulting in a bioavailability of 93%. The drug is metabolised in the liver and most of the metabolites are excreted in the urine. In clinical trials rofecoxib has reduced joint pain in osteoarthritis more than placebo.

Nps.org.au

Category:  Health Detail Drugs


Rofecoxib for osteoarthritis Cochrane

(9 days ago) Rofecoxib is often referred to as a 'COX II inhibitor' and is one of the new non-steroidal anti-inflammatory drugs (NSAIDs) prescribed to decrease pain and inflammation. Other NSAIDS, such as naproxen (Naprosyn) are also prescribed but they come with warnings that they may cause stomach problems such as ulcers, bleeds and sores that can be serious.

Cochrane.org

Category:  Health Detail Drugs


Lying with Statistics –the Vioxx Scandal

(2 days ago) drug period (17 in patients assigned to rofecoxib and five in patients assigned to placebo); 12 of these (11 in the rofecoxib group and one in the placebo group) occurred more than 48 weeks after treatment discontinuation.

Courses.washington.edu

Category:  Health Detail Drugs


Comparison of nonsteroidal anti-inflammatory drugs and

(Just Now) determined.Which drugs accounted for 90% of use was also calculated. RESULTS Overall NSAID use was different in Australia and Nova Scotia.However, ns-NSAID use was similar.COX-2 inhibitor dispensing was higher in Australia.The percentage of COX-2 inhibitor prescriptions over the total NSAID use was different in the two countries.High-risk NSAID

Bpspubs.onlinelibrary.wiley.com

Category:  Health Detail Drugs


METABOLISM OF ROFECOXIB IN VITRO USING HUMAN LIVER

(8 days ago) The metabolism of rofecoxib, a potent and selective inhibitor of cyclooxygenase-2, was examined in vitro using human liver subcellular fractions. The biotransformation of rofecoxib was highly dependent on the subcellular fraction and the redox system used. In liver microsomal incubations, NADPH-dependent oxidation of rofecoxib to 5-hydroxyrofecoxib …

Dmd.aspetjournals.org

Category:  Health Detail Drugs


Rofecoxib, Drugs 10.2165/00003495-200161060-00019 DeepDyve

(6 days ago) Drugs 2001; 61 (6) Mean pain scores Rofecoxib: A Review 851 4.2.3 Primary Dysmenorrhoea baseline was significantly less for naproxen so- As a treatment for primary dysmenorrhoea, dium (1 hour) than either rofecoxib or placebo (1.5 [46] rofecoxib has been compared with naproxen so- hours, p ≤ 0.006).

Deepdyve.com

Category:  Health Detail Drugs

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FAQ about Rofecoxib Drug

What is the drug Rofecoxib used for?

Rofecoxib (Vioxx) was introduced by Merck in 1999 as an effective, safer alternative to non-steroidal anti-inflammatory drugs for the treatment of pain associated with osteoarthritis. It was subsequently found to increase the risk of cardiovascular disease and withdrawn from the worldwide market.

What is Vioxx (rofecoxib)?

When Vioxx (rofecoxib) received its FDA approval in 1999, it was the second drug of its kind in a relatively new class of painkiller drugs called selective NSAIDs, or nonsteroidal anti-inflammatory drugs.

When was rofecoxib approved by the FDA?

List of authors. On May 21, 1999, Merck was granted approval by the Food and Drug Administration (FDA) to market rofecoxib (Vioxx).

Where can I find research on rofecoxib?

Go to: The VIGOR study In January 1999, Merck launched its largest study yet of rofecoxib, the Vioxx gastrointestinal outcomes research (VIGOR) study. The study was intended to expand the drug's approved indications by showing that it would have fewer gastrointestinal side effects than naproxen for the treatment of rheumatoid arthritis.