Rofecoxib Drug

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rofecoxib (Vioxx): Drug Facts, Side Effects and Dosing

(9 days ago) Rofecoxib is a nonsteroidal anti-inflammatory drug that is used to treat pain, particularly the pain of osteoarthritis and menstrual cramps. Prostaglandins are chemicals that are important in …

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Rofecoxib Side Effects: Common, Severe, Long Term

(3 days ago) Rofecoxib Side Effects. Applies to rofecoxib: oral suspension, oral tablet. Gastrointestinal. Gastrointestinal side effects have included diarrhea, dyspepsia, epigastric discomfort, …

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Rofecoxib Oral: Uses, Side Effects, Interactions, Pictures

(3 days ago) Find patient medical information for rofecoxib oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.

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Rofecoxib: Uses, Interactions, Mechanism of Action

(7 days ago) 1357 rows · Identification Summary. Rofecoxib is a COX-2 inhibitor NSAID used to treat …

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Vioxx (rofecoxib) Questions and Answers FDA - U.S.

(1 days ago) Vioxx (rofecoxib) Questions and Answers. [9/30/2004] 1. What action did Merck take today? Merck announced a voluntary worldwide withdrawal of Vioxx (rofecoxib). 2. What is Vioxx? …

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Drug Regulation: Rofecoxib (Vioxx) voluntarily withdrawn …

(2 days ago) Rofecoxib, which is available in more than 80 countries, had worldwide sales of $2.5 billion in 2003. IMS Health Canada reports that rofecoxib was the number 10 top-selling …

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Rofecoxib - brand name list from Drugs.com

(7 days ago) Rofecoxib. Chemical formula: C17H14O4S Drugbank ID: DB00533 ATC code: M01AH02. The information below refers to products available in the United States that contain rofecoxib. …

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Vioxx: Side Effects, Dosage & Uses - Drugs.com

(2 days ago) unexplained weight gain; swelling or water retention; unusual fatigue or lethargy; a skin rash or itching; yellowing of your skin or eyes; "flu-like" symptoms; or. unusual bruising or bleeding. Other, less serious side effects may be more likely to occur. Continue to take Vioxx and talk to your doctor if you experience.

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Rofecoxib C17H14O4S - PubChem

(1 days ago) Rofecoxib C17H14O4S CID 5090 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity …

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Population pharmacokinetic modelling of the …

(3 days ago) Drugs and dosages. For study A, rofecoxib was extracted from Vioxx tablets (12.5 mg Vioxx; Merck, Kirkland Quebec, Canada). Vioxx tablets were crushed to fine power, …

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VIOXX® - Food and Drug Administration

(7 days ago) VIOXX is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, and (Also see Drug Interactions.) Excretion Rofecoxib is eliminated …

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Vioxx (Rofecoxib): Uses, Dosage, Side Effects, Interactions - RxList

(7 days ago) Rofecoxib is eliminated predominantly by hepatic metabolism with little ( < 1%) unchanged drug recovered in the urine. Following a single radiolabeled dose of 125 mg, …

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Evidence in Vioxx Suits Shows Intervention by Merck Officials

(Just Now) More than 25 million Americans took Vioxx between 1999 and 2004, and at least 4,600 people or their survivors are suing Merck, claiming Vioxx caused their heart attacks or …

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Rofecoxib - an overview ScienceDirect Topics

(7 days ago) The drug is administered orally, its bioavailability is 93%, and 87% of the absorbed dose is bound to plasma proteins. 136 The metabolism of rofecoxib in the liver yields metabolites that have …

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DGIdb - ROFECOXIB Drug Record

(6 days ago) Konturek et al., 2003, Influence of COX-2 inhibition by rofecoxib on serum and tumor progastrin and gastrin levels and expression of PPARgamma and apoptosis-related proteins in gastric …

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FAQ about Rofecoxib Drug

What is the chemical name for rofecoxib?

VIOXX® (rofecoxib) is a nonsteroidal anti-inflammatory drug (NSAID). The chemical name is 4-[4(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone. The molecular weight is 314.36.

What is the mechanism of action of rofecoxib?

Rofecoxib is a nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic therapeutic effects. It has been proposed that rofecoxib inhibits the activity of the enzyme cyclooxygenase-2 (COX-2), resulting in a decreased formation of precursors of prostaglandins.

Is rofecoxib available by prescription?

Rofecoxib was available by prescription in both tablet-form and as an oral suspension. Rofecoxib gained widespread use among physicians treating patients with arthritis and other conditions causing chronic or acute pain. Worldwide, over 80 million people were prescribed rofecoxib at some time.

Is rofecoxib a COX-2 inhibitor?

Rofecoxib is a selective COX-2 inhibitor, or "coxib". Though the class of coxibs includes several agents, there are varying degrees of COX-2 selectivity among them, with celecoxib (Celebrex) being the least COX-2 selective, and rofecoxib (Vioxx), valdecoxib (Bextra), and etoricoxib (Arcoxia), being highly COX-2 selective.