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More importantly, the use of single doses of 2 drugs administered concurrently (optimally albendazole with DEC or ivermectin) is 99% effective in removing microfilariae from the blood for a full year after treatment. It is this level of treatment effectiveness that has made feasible the new efforts to eliminate lymphatic filariasis.

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Infectious Disease and Antimicrobial Agents

(4 days ago) Other appropriate drugs would be hard to find, since true allergy to any one of the nitroimidazoles would probably mean a high degree of cross-allergenicity (e.g., to tinidazole). However, there has been at least one attempt at desensitizing patients with metronidazole allergy which shows promise. Women were treated with graduated, increasing

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Empiric Antibiotic Selection

(4 days ago) E mpiricism. Empiricism is the philosophical doctrine that states that all human knowledge comes from experience and theory is based upon observation. It is this philosophy that forms the …

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Pharmacodynamics of Antimicrobial Agents: Time-Dependent vs

(8 days ago) Pharmacodynamics correlates the concentration of the drug with its pharmacological or clinical effects. For an antibiotic, this correlation refers to the ability of the drug to kill or inhibit the …

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Antibiotic Therapy for Positive Blood Cultures

(Just Now) The appropriate selection of e mpiric antibiotic therapy for positive blood cultures is a complex and difficult decision. Bacteria are only partially identified on Gram stain and speciation and …

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Anaerobic Bacteria

(Just Now) Most of the drugs that are active against anaerobes have good bactericidal activity, except chloramphenicol. Prescription of antimicrobial agents must always be based on distinct clinical …

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Escherichia coli

(5 days ago) The carbapenems are widely regarded as the drugs of choice for the empiric treatment of severe infections due to AmpC- and ESBL-producing E. coli . It is reasonable to suggest that …

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Antimonials (Meglumine antimoniate, Sodium stibogluconate)

(2 days ago) No interactions are known, but drugs which may impair renal function or prolong the QT interval should be used with caution. Brand names/Manufacturer. Sodium stibogluconate: …

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Aggregatibacter actinomycetemcomitans

(Just Now) Combination Drugs. Yogev et al. showed that rifampicin and ceftriaxone shared the lowest MIC90 value (1.6µg/mL) for 24 clinical isolates of A. actinomycetemcomitans . They therefore tested …

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Elizabethkingia, Chryseobacterium and Myroides species

(Just Now) The newly classified and renamed Elizabethkingia, Chryseobacterium and Myroides genera were originally included among the different species that belong to the genus Flavobacterium. The …

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Dematiaceous fungi: Chromoblastomycosis, Mycetoma

(4 days ago) Combination Drugs. This is a potentially useful strategy for refractory infections, though it has not been studied extensively in dematiaceous fungi. The combination of itraconazole or …

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Morganella species

(5 days ago) Morganella usually causes skin and soft tissue infections. Falagas reported 13 patients (54%) suffered from skin and soft tissue infections in a 4-year period at Greece hospital ( 23 ). In a …

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Nonnucleoside Analogues (Delavirdine, Efavirenz, Etravirine, …

(Just Now) For both drugs, children require a higher dose on a weight or body surface area basis than adults to maintain acceptable plasma concentrations. In a pharmacokinetic study of multiple-dose …

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Acinetobacter species

(4 days ago) Combination Drugs. Combination therapy is suggested when the infections are caused by A. baumannii non-susceptible to all conventional drugs. In vitro and in vivo (animal) studies have …

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C. trachomatis- Infectious Disease and Antimicrobial Agents

(Just Now) Microbiology. Chlamydia trachomatis is one of several species within the genus Chlamydia that cause human disease, but it is the only one that only infects humans. The others are …

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Providencia species

(1 days ago) Antimicrobial resistance patterns for 319 Providencia isolates collected over a 10-year period in Portugal are reported in Table 1 ( 43 ). Over 90% of isolates were resistant to aminoglycosides …

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Mycobacterium marinum

(5 days ago) Mycobacterium marinum, a non-tuberculous pathochromogen with an intermediate growth rate between rapidly and slowly growing mycobacteria, belongs to group I of the Runyon …

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Mycobacterium Tuberculosis Complex

(1 days ago) The fluoroquinolones and rifabutin, drugs that are commonly used to treat drug-resistant tuberculosis and HIV-related tuberculosis, respectively, do not have FDA approval for the …

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Infections Associated with Specific Immunosuppressive Agents in

(Just Now) Determining the actual risk of infection for each of these medications is challenging as there are many overlapping factors. ATG and alemtuzumab in general have a greater impact on the risk …

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A Differential Diagnosis of Drug-Induced Aseptic Meningitis

(1 days ago) intrathecal administration of drugs. The other is that the meninges are expressing an immunological hyper-sensitivity—most often a type 3 or type 4 hypersensitivity reaction—to …

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Trimethoprim (TMP) – Sulfamethoxazole (SMX) Rev 4-2015

(4 days ago) Trimethoprim (TMP) Sulfamethoxazole (SMX) Antibiotic Class: Antibiotic (trimethoprim and sulfonamide combination in a 1:5 ratio) Antimicrobial Spectrum:

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