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Important drug nutrient interactions

Gastrointestinal drug metabolising enzymes and transporters n Cytochrome P450 (CYP)3A4 – regulates oral bioavailability of drugs and nutrients n Grapefruit juice n St John’s wort n P-glycoprotein n Inhibition (eg, water soluble vitamin E) n Increased bioavailability or ciclosporin1 and digoxin2 n Induction (eg, St John’s wort3) n Reduced bioavailability of ciclosporin, digoxin …

Actived: 7 days ago

URL: bapen.org.uk


Drugs and Nutrition How drug side effects can influence

(8 days ago) Drugs and Nutrition How drug side effects can influence nutritional intake Rebecca White Pharmacist Team Manager – Nutrition & Surgery. Oxford Radcliffe Hospitals NHS Trust. Factors Influencing Nutritional Intake • Food availability • Physical capability • Appetite • …

Category:  Hospital Go Now


Drug Disposition in Obesity & Protein-Calorie Malnutrition

(Just Now) – Lipophilic drugs • May or may not have larger V d (L/kg) – Hydrophilic drugs • May or may not have a larger V d (L/kg) Altered V d in Obesity Drug. …

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Parenteral Nutrition

(5 days ago) Inpatients may also have other intravenous drugs prescribed, containing significant amounts of electrolytes in variable volumes of fluid. Although the basal requirement for water is quoted as 25-35ml/kg/day, the above factors lead to wide variations in …

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Hospital Food as Treatment

(9 days ago) Effect of Drugs The use of drugs with side effects of anorexia, nausea and gastrointestinal symptoms should be minimised by careful review of drug charts, particularly in the case of elderly patients. Monitoring and Audit

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Nutritional Assessment

(9 days ago) History of alcohol misuse or drugs, including insulin, chemotherapy, antacids, or diuretics; If the patient is considered to be at high risk of refeeding syndrome, the following steps are advised by NICE (2006): Start nutrition support at a maximum of 10 kcal/kg/day, increasing levels slowly to meet or exceed full needs by 4–7 days

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Hospital Food as Treatment

(7 days ago) A patient's malnutrition may continue in hospital because of the types of treatment, the drugs that are administered and the tests which are undergone. A major contribution to worsening nutritional status during admission and stay for many patients is the inadequacy of current catering and feeding practices which are modelled on institutional

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Current Perspectives on Parenteral Nutrition in Adults

(7 days ago) The nutrition support pharmacist must be consulted about unusual requirements and the possible addition of drugs or other additives when the stability of the emulsion must be confirmed. All patients who receive parenteral nutrition must be carefully monitored. Monitoring should include clinical, laboratory, and nutritional parameters.

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Nutrition Support

(4 days ago) History of alcohol misuse or drugs, including insulin, chemotherapy, antacids, or diuretics; If the patient is considered to be at high risk of refeeding syndrome, the following steps are advised by NICE (2006): Start nutrition support at a maximum of 10 kcal/kg/day, increasing levels slowly to meet or exceed full needs by 4–7 days

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*The use of cyclizine in patients receiving parenteral

(7 days ago) drugs (H1 blockers) and was first sold 1965. It is marketed for the treatment or prevention of nausea, vomiting, and labyrinthine disorders including vertigo and motion sickness. This includes nausea after a general anaesthetic and that caused by opioid use. In the United Kingdom the oral

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Introduction to Malnutrition

(2 days ago) Malnutrition is a state of nutrition in which a deficiency or excess (or imbalance) of energy, protein and other nutrients causes measurable adverse effects on tissue / body form (body shape, size and composition) and function and clinical outcome. The term malnutrition does include obesity, however BAPEN is focussed on the problem of 'undernutrition'.

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Enteral Nutrition

(Just Now) Enteral Nutrition. Patients who either are unable to take any nutrition orally or who are unable to take sufficient nutrition orally, but in whom the gastrointestinal tract is functioning, may be fed enterally. This implies feeding into the gastrointestinal tract using a tube. Common underlying disease processes leading to enteral tube feeding

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Top Tips for Managing a High Output Stoma or Fistula

(1 days ago) of prokinetic drugs (e.g. metoclopramide). In the perioperative period, abdominal sepsis (with low albumin and ileus) may occur. Other causes include small bowel diverticula, coeliac disease or Clostridium difficile infection. B. Rehydrating and stopping thirst may be done acutely by giving intravenous saline while taking little or no oral intake.

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Complication Management

(7 days ago) Complication Management. Complications related to PN can be classified as insertion related, line related and metabolic complications. The latter are further divided into short-term and long-term, depending on the duration of PN. Insertion complications. Line …

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Drug-Nutrition Interactions in Nutrition Support

(1 days ago) Antiepileptic Drugs • Carbamazepine • Lower bioavailability when administered via NGT than orally (fasted) • Drug delivery improves when suspension diluted and tube flushed • Phenytoin • Subtherapeutic levels noted when administered with EN • Holding EN has not always improved phenytoin absorption

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Enteral tube feeding safety in COVID-19 patients (Updated

(2 days ago) misplacement in the lungs (or oesophagus) followed by infusion of nutrients, drugs or water – so called “Never Events”. We offer the following pragmatic advice: 1. Nutritional support should be offered as indicated in NICE 32, 2017. 2. Enteral tube feeding in COVID-19 patients in Critical Care and Intensive Care will be limited

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Parenteral Nutrition Formulation

(3 days ago) Inpatients may also have other intravenous drugs prescribed, containing significant amounts of electrolytes in variable volumes of fluid. Although the basal requirement for water is quoted as 25-35ml/kg/day, the above factors lead to wide variations in …

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PARENTERAL NUTRITION: VASCUAR ACCESS DEVICE SELECTION

(3 days ago) -Administration of fluid and/ toxic drugs-Short –term access 7-10days Classification of VADs. Intermediate-term VADs

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Parenteral Nutrition Monitoring

(4 days ago) Parenteral Nutrition Monitoring. Monitoring patients on parenteral nutrition (PN) requires a multidisciplinary approach with effective communication throughout the team. This will help to minimise potential complications, and will aid safe, effective and appropriate use of PN. The team should include, at minimum, input from a Doctor, Nurse

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Access Routes/Tube Types

(5 days ago) Access Routes/Tube Types. Enteral nutrition is often considered to be simpler than parenteral nutrition. Although nasogastric feeding is relatively common in hospital and gastrostomy feeding is the most common form of tube feeding in the community, in the past few decades more complex enteral access routes have become available and these may

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Feed Formulation

(Just Now) Inpatients may also have other intravenous drugs prescribed, containing significant amounts of electrolytes in variable volumes of fluid. Although the basal requirement for water is quoted as 25-35ml/kg/day, the above factors lead to wide variations in …

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Tube type Timeframe Common Common Hazards Key

(6 days ago) • avoid drugs if at all possible • 50ml enteral syringe + warm water ; Displacement • Retention devices may be useful ; Gastrostomy Long-term •– generally more than 30 days Longer term in neurological disease technique • SurgeryOesophageal pathology • Head and

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Enteral and Parenteral Nutrition

(9 days ago) The choice between enteral and parenteral nutrition. In general, enteral nutrition is preferred to parenteral nutrition as it is more physiological, simpler, cheaper and less complicated. However even nasogastric feeding needs care and the more complex types of enteral nutrition such as gastrostomy and jejunostomy need significant interventions.

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Enteral Nutrition

(3 days ago) Enteral feed is a sterile, specifically designed nutritional liquid that is licensed to be administered via an enteral feeding tube. It is often nutritionally complete in specified volumes. There are a wide variety of different ‘feeds’ available from a range of manufacturers to …

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British Intestinal Failure Alliance (BIFA) Position

(2 days ago) 2. If the QT interval is prolonged cardiac co-morbidities are considered, drugs known to prolong the QT interval are rationalised and metabolic causes (e.g. hypomagnesaemia) are treated. A cardiological opinion may be sought. 3. Patients already taking high dose loperamide should continue with it and the QT interval measured on an ECG.

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Top Tips for Managing Abnormal Liver Function Tests in

(1 days ago) nil by mouth or drugs) predispose to biliary sludge and thus to gallstones. B. Paediatric patients with intestinal failure used to have a higher prevalence of severe IFALD; and a quarter of those advanced to end-stage liver failure. Intrahepatic cholestasis and hyperbilirubinaemia are the

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Resources and Education

(5 days ago) Administering Drugs Via Enteral Feeding Tubes. Being updated, back soon. Current Perspectives on Paediatric Parenteral Nutrition. Published: 2000; Chairman and Editor: Professor PJ Milla. This report provided up to date information on current practice in paediatric parenteral nutrition.

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Enteral Feed Monitoring

(4 days ago) Ensure drugs are in an appropriate presentation for tube administration and absorption. Nausea and vomiting: Daily: Monitor tolerance of feed. Gastric residual volumes: 4 hourly where clinically indicated in acute setting. In some units used to assess gastric emptying and ascertain appropriateness of increasing feed rate. Feeding tube position

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Refeeding syndrome: Identification of those at risk – 1

(7 days ago) and any history of excess alcohol or drugs such as insulin, chemotherapy antacids and diuretics Patient is at risk of refeeding syndrome: refer immediately to the dietitian and/or nutrition team Ensure adequate thiamine and B vitamins before and during the first 10 days of

Category:  Vitamin Go Now


RCP Top 10 tips for Parenteral Nutrition

(8 days ago) 10. Abnormal LFTs on PN more commonly relate to pre -existing liver disease, drugs or sepsis than to the parenteral nutrition solutions. *: CRS is suggested by a temperature that begins ½ to 3 hours after the PN begins in those feeding at night only (cyclical PN) whereas in those fed continuously it is often a low grade persistent temperature.

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Final version of BIFA position statement on HPN in

(5 days ago) They may need to learn how to adjust to lifestyle events such as bathing, showering, swimming, partaking of sports and travel. In addition to the PN they may also have to cope with wound/stoma management, chronic pain and much medication (e.g. analgesics, proton pump inhibitors, anti-diarrhoeal and anti-emetic drugs).

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Constipation and connective tissue disorders

(2 days ago)Drugs: –Opiates –Anticholinergics –Antipsychotics –Liraglutide, but not gliptins • Renal failure • Pregnancy • Anorexia Nervosa, Very low BMI • Functional dyspepsia • Iatrogenic. Assessment of gastric emptying. Assessment of gastric emptying –breath test Normal

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Top Tips for Preventingand Managing Refeeding Syndrome

(1 days ago) † A history of alcohol abuse or drugs including insulin, chemotherapy, antacids or diuretics. 7. The UK NICE guidelines are considered by many to be cautious in the amount of energy given when feeding first begins. The non-protein energy is generally given as 50% carbohydrate and 50% lipid to reduce

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RCP 10 top tips for

(Just Now) Some drugs affect specific nutrients e.g. metformin is linked to vitamin B12 deficiency. Some anti-epileptic and antituberculosis drugs increase requirement for folate. Evidence-based Practice . 10. Remember that any assessment must include a …

Category:  Vitamin Go Now


British Intestinal Failure Alliance (BIFA) Position

(6 days ago) drugs system and their Blueteq number should be added to all prescriptions and invoices (in NHS England only). 5. HPN units should work together to standardise practice. Team 6. The adult team should consist of a consultant (with dedicated sessions), one (ideally 2 or

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About Malnutrition

(8 days ago) Brain. Malnutrition causes apathy, depression, introversion, self-neglect and deterioration in social interactions. Reproduction. Malnutrition reduces fertility and if present during pregnancy can predispose to problems with diabetes, heart disease and stroke in the baby in later life.

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BAPEN SUMMARY PROGRAMME

(4 days ago) Drugs and nutrition support BAPEN Medical AGM Keynote Lecture Improving fluid management: something for everyone? Dr Marcia McDougall Scotland BAPEN 2021 Recognition & Awards Symposium 13 Quandaries in clinical nutrition Close of Conference Stanmer Symposium 8 Outpatient follow up of home parenteral support (HPS) Symposium 11 Nutritional support in

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Top Tips for the Use of Parenteral Nutrition in Critically

(2 days ago) suspected to be poor, drugs that reduce gut motility (e.g. opiates and cyclizine) and level of sedation (high levels delay gastric emptying) are reviewed, but it can be difficult to reduce the doses. Promotility drugs (metoclopramide or erythromycin), laxatives/enemas for constipation and a peptide EN feed may be tried to optimise GI tolerance.

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