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Anti-Aging Drugs

(1 days ago) Objective: The purpose of this study is to explore pharmacological discoveries which may help to the delay or improvement of the aging process. More specifically, the authors focus on three …

Category:  Health Go Now

Drug glucuronidation in humans

(Just Now) Glucuronidation is a major metabolic pathway for a large number of drugs in humans. Conjugation of drugs and other chemicals with glucuronic acid is catalyzed by the multigene …

Category:  Health Go Now

Drugs That Induce or Cause Deterioration of Myasthenia Gravis: …

(1 days ago) A number of drugs such as immune checkpoint inhibitors, penicillamine, tyrosine kinase inhibitors and interferons may induce de novo MG by altering the immune homeostasis …

Category:  Health Go Now

Drug-induced pancreatitis: an update

(1 days ago) Abstract. Background and aims: Many frequently prescribed drugs are suspected to cause acute pancreatitis (AP). The goal of this paper is to bring to light the often occult but real problem of …

Category:  Health Go Now

Antibody-Drug Conjugates: A Comprehensive Review

(1 days ago) Antibody-drug conjugates (ADC) are one of the fastest growing anticancer drugs. This approach comprises a mAb conjugated to the cytotoxic payload via a chemical linker that directed …

Category:  Cancer Go Now

Antiarrhythmic Drugs: Risks and Benefits

(1 days ago) The narrow therapeutic window of antiarrhythmic drugs makes their use clinically challenging. A solid understanding of the mechanisms of arrhythmias and how antiarrhythmics affect these …

Category:  Health Go Now

Recommendations for the Management of Drug-Drug Interactions …

(1 days ago) The coronavirus disease 2019 (COVID-19) antiviral nirmatrelvir/ritonavir (Paxlovid) has been granted authorization or approval in several countries for the treatment of patients with mild to …

Category:  Health Go Now

Alzheimer's disease drug development pipeline: 2022

(1 days ago) We use the Common Alzheimer's Disease Research Ontology (CADRO) to classify drug targets and mechanisms of action of drugs in the pipeline. Results: As of …

Category:  Health Go Now

Triglyceride Lowering Drugs

(1 days ago) The two major goals of the treatment of hypertriglyceridemia are the prevention of cardiovascular disease and pancreatitis. Here we discuss the drugs used for the treatment of …

Category:  Health Go Now

Drug-Induced Acute Kidney Injury

(1 days ago) Drug-induced AKI may also develop through induction of inflammation within the tubulointerstitium. Medications can elicit a T cell-mediated immune response that promotes the …

Category:  Medications Go Now

Editorial: drug-induced acute pancreatitis: uncommon or …

(1 days ago) Many drugs have been implicated as causing acute pancreatitis (AP), mainly based on the recurrence of pancreatitis following rechallenge with a drug that the patient had been taking at …

Category:  Health Go Now

Cytochrome P450 Enzymes and Drug Metabolism in Humans

(1 days ago) Human cytochrome P450 (CYP) enzymes, as membrane-bound hemoproteins, play important roles in the detoxification of drugs, cellular metabolism, and homeostasis. In …

Category:  Health Go Now

A review of drug-induced hyponatremia

(1 days ago) Hyponatremia (defined as a serum sodium level < 134 mmol/L) is the most common electrolyte abnormality in hospitalized patients. Certain drugs (eg, diuretics, antidepressants, and …

Category:  Hospital Go Now

Advances on Epigenetic Drugs for Pediatric Brain Tumors

(1 days ago) Epigenetic drugs, including inhibitors of DNA methyltransferases, histone deacetylases and demethylases, are currently being tested in clinical trials on pediatric brain tumors. Additional …

Category:  Health Go Now

Drug-induced methaemoglobinaemia. Treatment issues

(Just Now) The most clinically relevant direct methaemoglobin formers include local anaesthetics (such as benzocaine and, to a much lesser extent, prilocaine) as well as amyl nitrite and isobutyl nitrite, …

Category:  Health Go Now

Prescription of Controlled Substances: Benefits and Risks

(1 days ago) Controlled substances: These are drugs or medications that possess the potential for being misused and are considered to be substances that have a substantially high risk of …

Category:  Medications Go Now

Review article: promotility drugs in the treatment of gastro

(Just Now) Abstract. Prokinetic agents are drugs that increase contractile force and accelerate intraluminal transit. They are often used in treating disorders of gastrointestinal motility including gastro …

Category:  Health Go Now

Aluminium in over-the-counter drugs: risks outweigh benefits

(1 days ago) Over-the-counter antacids are the most important source for human aluminium exposure from a quantitative point of view. However, aluminium can act as a powerful neurological toxicant and …

Category:  Health Go Now

Efficacy and safety of three new oral antiviral treatment …

(1 days ago) These three oral antiviral drugs are still being studied, and the available data suggest that they will bring new hope for COVID-19 recovery and have the potential to be a breakthrough and …

Category:  Health Go Now

Failure of Investigational Drugs in Late-Stage Clinical

(1 days ago) Roughly half of investigational drugs entering late-stage clinical development fail during or after pivotal clinical trials, primarily because of concerns about safety, efficacy, or …

Category:  Health Go Now

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