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Anti-Aging Drugs

(1 days ago) Objective: The purpose of this study is to explore pharmacological discoveries which may help to the delay or improvement of the aging process. More specifically, the authors focus on three …

Category: Health Go Now

Drug glucuronidation in humans

(Just Now) Glucuronidation is a major metabolic pathway for a large number of drugs in humans. Conjugation of drugs and other chemicals with glucuronic acid is catalyzed by the multigene …

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Drugs That Induce or Cause Deterioration of Myasthenia Gravis: …

(1 days ago) A number of drugs such as immune checkpoint inhibitors, penicillamine, tyrosine kinase inhibitors and interferons may induce de novo MG by altering the immune homeostasis …

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Drug-induced pancreatitis: an update

(1 days ago) Abstract. Background and aims: Many frequently prescribed drugs are suspected to cause acute pancreatitis (AP). The goal of this paper is to bring to light the often occult but real problem of …

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Antibody-Drug Conjugates: A Comprehensive Review

(1 days ago) Antibody-drug conjugates (ADC) are one of the fastest growing anticancer drugs. This approach comprises a mAb conjugated to the cytotoxic payload via a chemical linker that directed …

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Antiarrhythmic Drugs: Risks and Benefits

(1 days ago) The narrow therapeutic window of antiarrhythmic drugs makes their use clinically challenging. A solid understanding of the mechanisms of arrhythmias and how antiarrhythmics affect these …

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Recommendations for the Management of Drug-Drug Interactions …

(1 days ago) The coronavirus disease 2019 (COVID-19) antiviral nirmatrelvir/ritonavir (Paxlovid) has been granted authorization or approval in several countries for the treatment of patients with mild to …

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Alzheimer's disease drug development pipeline: 2022

(1 days ago) We use the Common Alzheimer's Disease Research Ontology (CADRO) to classify drug targets and mechanisms of action of drugs in the pipeline. Results: As of …

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Triglyceride Lowering Drugs

(1 days ago) The two major goals of the treatment of hypertriglyceridemia are the prevention of cardiovascular disease and pancreatitis. Here we discuss the drugs used for the treatment of …

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Drug-Induced Acute Kidney Injury

(1 days ago) Drug-induced AKI may also develop through induction of inflammation within the tubulointerstitium. Medications can elicit a T cell-mediated immune response that promotes the …

Category: Medications Go Now

Editorial: drug-induced acute pancreatitis: uncommon or …

(1 days ago) Many drugs have been implicated as causing acute pancreatitis (AP), mainly based on the recurrence of pancreatitis following rechallenge with a drug that the patient had been taking at …

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Cytochrome P450 Enzymes and Drug Metabolism in Humans

(1 days ago) Human cytochrome P450 (CYP) enzymes, as membrane-bound hemoproteins, play important roles in the detoxification of drugs, cellular metabolism, and homeostasis. In …

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A review of drug-induced hyponatremia

(1 days ago) Hyponatremia (defined as a serum sodium level < 134 mmol/L) is the most common electrolyte abnormality in hospitalized patients. Certain drugs (eg, diuretics, antidepressants, and …

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Advances on Epigenetic Drugs for Pediatric Brain Tumors

(1 days ago) Epigenetic drugs, including inhibitors of DNA methyltransferases, histone deacetylases and demethylases, are currently being tested in clinical trials on pediatric brain tumors. Additional …

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Drug-induced methaemoglobinaemia. Treatment issues

(Just Now) The most clinically relevant direct methaemoglobin formers include local anaesthetics (such as benzocaine and, to a much lesser extent, prilocaine) as well as amyl nitrite and isobutyl nitrite, …

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Prescription of Controlled Substances: Benefits and Risks

(1 days ago) Controlled substances: These are drugs or medications that possess the potential for being misused and are considered to be substances that have a substantially high risk of …

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Review article: promotility drugs in the treatment of gastro

(Just Now) Abstract. Prokinetic agents are drugs that increase contractile force and accelerate intraluminal transit. They are often used in treating disorders of gastrointestinal motility including gastro …

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Aluminium in over-the-counter drugs: risks outweigh benefits

(1 days ago) Over-the-counter antacids are the most important source for human aluminium exposure from a quantitative point of view. However, aluminium can act as a powerful neurological toxicant and …

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Efficacy and safety of three new oral antiviral treatment …

(1 days ago) These three oral antiviral drugs are still being studied, and the available data suggest that they will bring new hope for COVID-19 recovery and have the potential to be a breakthrough and …

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Failure of Investigational Drugs in Late-Stage Clinical

(1 days ago) Roughly half of investigational drugs entering late-stage clinical development fail during or after pivotal clinical trials, primarily because of concerns about safety, efficacy, or …

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