Drugs targeted against G-protein coupled receptors, nuclear (hormone) receptors, and ion channels represent slightly less than 50% of the marketed drugs. By far, drugs directed against enzymes represent the largest portion of marketed drugs . Expansion into new types of drug targets may be necessary to fill certain therapeutic voids, but a
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Therapeutic Drug Monitoring
(7 days ago) Many drugs have active metabolites, and some drugs are actually given as pro-drugs, in which the parent compound has zero or minimal activity and pharmacological activity resides in a product of metabolic transformation. For example, mycophenolate mofetil is metabolized to the active immunosuppressant mycophenolate.
Design and discovery of boronic acid drugs
(7 days ago) Boronic acids as drugs are becoming increasingly relevant. In fact, four boron-containing drugs have been approved in the past five years, (Bortezomib as approved in 2005), with several others in clinical trials. Download : Download high-res image (195KB) Download : …
Synthesis of Essential Drugs ScienceDirect
(7 days ago) Drugs that are used for treating respiratory system illnesses can be classified as antiedematous drugs, anti-cough and expectorant agents, as well as bronchiolytics and other drugs used to treat bronchial asthma, such as methylxanthine, anticholinergic drugs, adrenergic drugs, allergy mediator releasing inhibitors, and corticosteroids.
P2Y12 antagonists: Approved drugs, potential naturally
(7 days ago) This test is the most specific test for measuring the inhibition of P2Y 12 by drugs such as clopidogrel . VASP's phosphorylation-state of whole blood can be tested using Western blot or flow cytometry . In flow cytometric assay blood samples are collected in 3.8% sodium citrate and incubated in-vitro with ADP and/or PGE1 before fixation.
Wastewater-based epidemiology for illicit drugs: A
(7 days ago) Drugs of abuse and their metabolites in the Ebro River basin : occurrence in sewage and surface water, sewage treatment plants removal ef fi ciency, and collective drug usage estimation Environ. Int. , 36 ( 1 ) ( 2010 ) , pp. 75 - 84 , 10.1016/j.envint.2009.10.004
Residues of veterinary drugs and heavy metals in bovine
(7 days ago) Veterinary drugs are used for disease control in bovines Their presence at acceptable levels is a cause of concern for consumers and control agencies, as well as being a limitation for accessing international markets. The objective of this research was to evaluate the presence of residues of veterinary drugs and heavy metals in meat cuts from
Biologics vs. small molecules: Drug costs and patient
(7 days ago) Most patented drugs in the market and their generics are small molecules ( 8 ). Technically, biologics differ from small molecules based on size and manufacturing process ( Table 1 ). While biologics are typically greater than 1 kDa in size, small molecules are relatively smaller, usually between 0.1 and 1 kDa ( 9 ).
Meyler's Side Effects of Drugs ScienceDirect
(7 days ago) Key Features. Enhanced encyclopedic format with drug monographs now organised alphabetically. Completely expanded coverage of each drug - thalidomide warranted three sentences in Meyler's 14th edition, but is now a 13 page extensive monograph. Clearer, systematic organization of information for easier reading including case histories to provide
Marine-derived drugs: Recent advances in cancer therapy
(7 days ago) Presently, anticancer drugs from marine sources have been utilized to precisely regulate endogenous immune mechanisms against various fatal cancer. In addition, numerous drugs, for example, Apratoxin A, GV-c9, and GV-c1, LS-1, SD, have established critical anticancer features by hindering the JAK/STAT innate immune signaling pathway.
Combining repurposed drugs to treat colorectal cancer
(7 days ago) Antiviral drugs. Amantadine is used to treat dyskinesia (involuntary muscle movements) associated with Parkinson’s disease and influenza caused by type A influenza virus. Its use as an antiviral drug is no longer recommended because of widespread drug resistance. Pleconaril is an antiviral drug for the prevention of asthma exacerbations and
Nano Drugs: A Critical Review of Their Patents and Market
(Just Now) Nano drugs are a revolutionary and ubiquitous science of the 21st century; a nano drug is the application of nanotechnology in the medicinal field that has the potential to significantly change the course of diagnostics and treatment of various life-threating diseases.
Neutrophil-Membrane-Directed Bioorthogonal Synthesis of
(7 days ago) Introduction. The systemic administration of drugs frequently suffers from limited target selectivity and potential off-target toxicity. Thus, random biodistribution, rapid deactivation, poor pharmacokinetics, low bioavailability, and premature clearance of the drug lead to poor therapeutic efficacy.1, 2, 3 A powerful alternative approach to boosting the therapeutic efficacy and alleviating
The Actions and Uses of Ophthalmic Drugs ScienceDirect
(9 days ago) Ophthalmic drugs (cycloplegics, mydriatics, miotics) directly or indirectly, stimulate or inhibit a part of the autonomic nervous system connected to the intra-ocular muscles. The text investigates in detail the structure and function of this involuntary nervous system in …
Illegal drugs and public corruption: Crack based evidence
(7 days ago) To estimate the causal effect of drugs on public corruption, we adopt the synthetic control method and exploit the fact that crack cocaine markets emerged in California in 1981, before reaching any other U.S. state. Our results show that public corruption more than tripled in California in the first three years following the arrival of crack
Optical Isomerism in Drugs
(Just Now) Many drugs having a center of asymmetry are still used in clinical practice as racemates. Racemic mixtures were estimated to represent 10–15 percent of all marketed drugs  . For certain types of therapeutics, such as the β-adrenergic agents, β-adrenergic blockers, antiepileptics, and oral anticoagulants, up to 90 percent of the compounds
Inhibitors Targeting RIPK1/RIPK3: Old and New Drugs
(7 days ago) First, in cell-free assays, these drugs inhibit their primary targets log scales more efficiently than do RIPK1/RIPK3 , questioning whether a therapeutic dose can be reached. Second, lowering doses for prolonged treatment in chronic inflammatory diseases may still result in toxicity compared with short-term high-dose treatments during cancer.