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Drug Consumption

(Just Now) A. Uutela, in International Encyclopedia of the Social & Behavioral Sciences, 2001. Illicit drugs are substances that either stimulate (such as cocaine or amphetamines) or inhibit (such as heroin or sedative-hypnotics) the central nervous system or cause hallucinogenic effects (such as marijuana or LSD) to the effect that their use has been

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Drug-Drug Interaction

(6 days ago) Robert M. Kliegman MD, in Nelson Textbook of Pediatrics, 2020 Drug-Drug Interactions. Pharmacokinetic and pharmacodynamic properties of drugs may be altered when ≥2 drugs are administered to a patient (Table 73.6).Interactions largely occur at the level of drugmetabolism but may occur at the level of drugabsorption (e.g., inhibition of intestinal CYP3A4 activity by …

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Drug Intoxication

(7 days ago) In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. Drug overdose. Suicide is the leading cause of premature death among patients with schizophrenia. The lifetime incidence of completed suicide among patients with schizophrenia is about 10% [658] and 18–55% of patients with schizophrenia make suicide attempts [659], sometimes with neuroleptic drugs.

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Counterfeit Drug

(6 days ago) Gerard Bodeker, Bertrand Graz, in Hunter's Tropical Medicine and Emerging Infectious Diseases (Tenth Edition), 2020. Counterfeit or “Fake” Medicines. It is estimated that counterfeit drugs provide approximately $75 billion in revenue annually to illegal operators and have caused more than 100,000 deaths worldwide. 15. Irregularities have also been detected in traditional …

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Oral ulcerations due to drug medications

(7 days ago) Clinical features of drug-induced oral ulceration. Typical oral ulcers due to drugs are clinically classified into two types. The first is widespread mucositis and ulceration, mainly caused by cytotoxic drugs used for anti-tumor chemotherapy. Widespread sloughing and ulceration arise within days of commencing therapy, with the associated pain

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Drug of Abuse Testing

(1 days ago) Amitava Dasgupta, in Alcohol, Drugs, Genes and the Clinical Laboratory, 2017. Introduction. There are two types of drugs of abuse testing: medical drug testing and legal drug testing. Medical drug testing is often conducted in a hospital clinical laboratory to screen for presence of any drug in the urine specimen of a person admitted to the emergency department with a …

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Adverse Effect of Drug

(2 days ago) The adverse effects of drugs that affect autonomic functions or the extrapyramidal system are reviewed based on literature published mainly from January 2015 to December 2015. Adrenaline is reported to Takotsubo syndrome and Kounis syndrome as has been in recent years. Droxidopa is a prodrug of noradrenaline and is newly listed in this section.

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Drugs Toxicology

(4 days ago) Steffen W. Ernst, Laura Stephenson, in Principles of Translational Science in Medicine (Third Edition), 2021. The broken safety value chain. As alluded to in the previous (Chapter 22, Pharmaceutical Toxicology), many companies invest heavily in predictive safety in the early stages of drug discovery.Safety criteria drive, at least in part, the thorough assessment of …

Category:  Pharmaceutical Go Now


Drug Concentration

(9 days ago) When drugs follow first-order kinetics, the concentration time curve shows an exponential decrease in the plasma drug concentration over time, and a linear decrease in drug concentration on logarithmic scale (see Fig. 45.5). The half-life of drug elimination is independent of drug dosage. Most drugs used in neonates follow first-order kinetic

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Drugs and the Future ScienceDirect

(9 days ago) Chapter 1 - Drugs Futures 2025. Significant advances in the understanding of areas such as neuroscience, genetics, pharmacology, psychology, and social policy have taken place in recent years. This new knowledge has moved one to a new level in the understanding of how the brain work, how chemicals affect the brain's performance and, in turn

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Pharmaceutical Manufacturing

(6 days ago) Buket Aksu, Gizem Yeğen, in Pharmaceutical Quality by Design, 2019. 1 Introduction. Pharmaceutical manufacturing process involves processes requiring high costs. The research and testing work that needs to be done to deliver a new drug to patients takes 10–15 years on average and requires a budget of over 800 million dollar. As the drug must be manufactured …

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Drug Concentration

(6 days ago) Rarely, drugs may follow what is called zero-order kinetics or nonlinear, saturable kinetics. In drugs that follow zero-order kinetics, a constant amount of drug is metabolized or eliminated per unit of time regardless of concentration. The drug concentration follows a linear decrease of serum concentration over time (see Fig. 45.4 ).

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Non Prescription Drug

(9 days ago) Some drugs remain marketed as both prescription drugs and nonprescription drugs, with the OTC version of the drug available in a different formulation or with a lowered dosage strength. The movement of drugs from prescription-only to nonprescription OTC drugs is a continual process, with monthly announcements by the FDA of the drugs making this

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Antiplatelet Drug

(7 days ago) Platelet mapping is a special TEG assay that measures the effects of antiplatelet drug therapy (aspirin, ADP receptor inhibitors and GpIIb/IIIa inhibitors) on platelet function. The plasma anti-Xa assay may be used for monitoring therapy with unfractionated heparin (UFH) or low-molecular-weight heparin. For an in-depth discussion on coagulation

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Sympathomimetic Drug

(Just Now) Sympathomimetic drugs are agents which in general mimic responses due to stimulation of sympathetic nerves. These agents are able to directly activate adrenergic receptors or to indirectly activate them by increasing norepinephrine and epinephrine (mediators of the sympathoadrenal system) levels. Chemically these drugs are catecholamines

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In Vitro Drug Testing

(9 days ago) The Importance of Drug Concentration. When testing drugs in vitro, the drug is confined to a known volume (ie, well of a plate, test tube, etc.), therefore the concentration of the drug is known. This is critical since all measures of drug activity (ie, potency, efficacy, affinity) are basically concentrations at which a defined drug effect is

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“No drugs in my back yard:” The ambivalent reception of cannabis

(7 days ago) First, the ban raised the number of crimes related to hard drugs by almost 24%, which corroborates the idea that hard drugs are a substitute for soft drugs. Second, the zero-tolerance policy reduced by 9% the number of jobs in those municipalities. Therefore, overall economic activity suffers from strict constraints on the drug market, and the

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Why 90% of clinical drug development fails and how to improve it

(7 days ago) 1. Why 90% of clinical drug development fails? Drug discovery and development is a long, costly, and high-risk process that takes over 10–15 years with an average cost of over $1–2 billion for each new drug to be approved for clinical use 1.For any pharmaceutical company or academic institution, it is a big achievement to advance a drug candidate to phase I clinical …

Category:  Pharmaceutical Go Now


Fabric phase sorptive extraction (FPSE) as an efficient sample

(7 days ago) 1.Introduction. Antidepressants drugs (ADs) are the most widely prescribed drugs to treat major depressive disorder (MDD) , a disabling disease that affect around 264 million people of all ages, representing one of the most serious public health problems [2, 3].To date, the etiology of MDD is not yet completely clear, even if there are several theories that could …

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